ESMplusplus large EU AI Act Compliance Profile

NOTE

The GitHub with the implementation and requirements.txt can be found here

ESM++

ESM++ is a faithful implementation of ESMC (license) that allows for batching and standard Huggingface compatibility without requiring the ESM Python package. The large version corresponds to the 600 million parameter version of ESMC.

Attention backends

sdpa (PyTorch Scaled Dot Product Attention) is the default. The backend is set via config.attn_backend before loading.

| Backend | Key | Notes | | :--- | :--- | :--- | | PyTorch SDPA | "sdpa" | Default. Exact numerics, stable on all hardware. | | Flash Attention | "kernels_flash" | Fastest on Ampere/Hopper GPUs. Requires pip install kernels (pre-built — no hours-long compilation). Outputs are not bitwise identical to SDPA due to online softmax reordering; differences are often small but not guaranteed to be inconsequential — use "sdpa" if exact numerics matter. | | Flex Attention | "flex" | Skips padding tokens via block mask — faster on variable-length batches. Near-exact numerics. First use compiles a Triton kernel (30–120 s). Best combined with torch.compile. | | Auto | "auto" | Picks the best available: kernels_flash → flex → sdpa. |

from transformers import AutoConfig, AutoModelForMaskedLM

config = AutoConfig.from_pretrained('Synthyra/ESMplusplus_large', trust_remote_code=True)
config.attn_backend = "flex"  # or "kernels_flash", "sdpa", "auto"
model = AutoModelForMaskedLM.from_pretrained('Synthyra/ESMplusplus_large', config=config, trust_remote_code=True)

torch.compile(model) is heavily recommended for sustained throughput, especially with Flex Attention.

Use with 🤗 transformers

from transformers import Au

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